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Chemistry and Biological Activity of Steroids

Chemistry and Biological Activity of Steroids

Author: Jorge António Ribeiro Salvador

Publisher: BoD – Books on Demand

ISBN: 9781789855159

Category: Science

Page: 142

View: 807

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The steroid scaffold continues to be the structural basis of new drugs for a variety of targets and diseases. Indeed, steroids interact with enzymes and receptors in a strikingly specific manner. Chemistry and Biological Activity of Steroids aims to provide an updated overview of recent advances in the medicinal chemistry of steroids. Novel synthetic methods in the steroids field, including steroid biotransformations, new steroids able to tackle steroid receptors, and steroid enzymes with clinical relevance, are critically reviewed in this book. Furthermore, the diverse physiopathological roles of oxysterols and their therapeutic value are also discussed.

Research Grants Index

Research Grants Index

Author: National Institutes of Health (U.S.). Division of Research Grants

Publisher:

ISBN: UIUC:30112106639237

Category: Medicine

Page:

View: 190

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Steroid Chemistry at a Glance

Steroid Chemistry at a Glance

Author: Daniel Lednicer

Publisher: John Wiley & Sons

ISBN: 9781119957294

Category: Science

Page: 152

View: 688

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The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted as "Steroid Chemistry". Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Topics covered include: history, isolation and structure determination of steroids steroid nomenclature and stereochemistry natural sources of steroids synthesis and reactions of aromatic a-ring steroids, androstanes, and pregnanes steroids with a spirolactone at position 17 steroids with hetrocyclic ring A compounds derived from cholesterol Based on the highly successful and student friendly "at a glance" approach, the information is presented in integrated, self contained double page spreads of text and illustrative material. Students of chemistry and pharmacy using Steroid Chemistry at a Glance will find they have a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural products. It will also serve as a handy bench reference for postgraduates and professional chemists.

Green Chemistry and Computational Chemistry

Green Chemistry and Computational Chemistry

Author: Liliana L. Mammino

Publisher: Elsevier

ISBN: 9780323851824

Category: Science

Page: 508

View: 904

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Green chemistry already draws on many techniques and approaches developed by theoretical chemists, whilst simultaneously revealing a whole range of interesting new challenges for theoretical chemists to explore. Highlighting how work at the intersection of these fields has already produced beneficial results, Green Chemistry and Computational Chemistry: Shared Lessons in Sustainability is a practical, informative guide to combining green and theoretical chemistry principles and approaches in the development of more sustainable practices. Beginning with an introduction to both theoretical chemistry and green chemistry, the book goes on to explore current approaches being taken by theoretical chemists to address green and sustainable chemistry issues, before moving on to highlight ways in which green chemists are employing the knowledge and techniques of theoretical chemistry to help in developing greener processes. The future possibilities for theoretical chemistry in addressing sustainability issues are discussed, before a selection of case studies provides good insight into how these interactions and approaches have been successfully used in practice. Highlights the benefits of green and theoretical chemistry groups working together to tackle sustainability issues across both academia and industry Supports readers in easily selecting the most appropriate path through the book for their own needs Presents a range of examples examining the practical implications and outcomes of interdisciplinary approaches

Anabolic Steroid Abuse

Anabolic Steroid Abuse

Author: Geraline C. Lin

Publisher: DIANE Publishing

ISBN: 0788129694

Category: Self-Help

Page: 249

View: 739

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Addresses the question of whether or not anabolic steroids in themselves possess abuse potential or if they simply play a role in the abuse of other substances. A historical overview of the discovery and development of the drug is provided, plus an evaluation of the drug's performance-enhancing effects. Health risks associated with the abuse of anabolic steroids are covered along with the biological reasons why steroids affect the body the way they do. Behavioral effects are also discussed. Charts, graphs and diagrams.

Metabolism of Anabolic-Androgenic Steroids

Metabolism of Anabolic-Androgenic Steroids

Author: Victor A. Rogozkin

Publisher: CRC Press

ISBN: 0849364159

Category: Medical

Page: 202

View: 755

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This book presents an authoritative review of the research regarding the influences of anabolic-androgenic steroids on metabolism. The book provides a concise description of the biochemistry of these steroids using simple terms and includes methods of separation and their clinical applications. The first section of the book examines the general structure, nomenclature, and classification of anabolic-androgenic steroids. Subsequent chapters explore concepts basic to understanding the pathways of their metabolism in both target and non-target tissues, including the interactions of steroids with receptors and the effects of steroids on the cellular metabolism of skeletal muscle. The changes and molecular base of modifications in metabolism during exercise involving anabolic-androgenic steroids are also described. Finally, a comprehensive review of methods for scanning and identifying anabolic-androgenic steroids in biological fluids is presented, as well as a discussion regarding the applicability and limitations of these techniques. The book provides valuable reference information for all scientists and clinicians engaged in sports medicine, exercise biochemistry, and endocrinology.

Glucocorticoids

Glucocorticoids

Author: N.J. Goulding

Publisher: Birkhäuser

ISBN: 9783034883481

Category: Medical

Page: 205

View: 873

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Following 50 years of glucocorticoid use in a clinical setting, an international body of expert scientists and physicians presents the most expansive survey of glucocorticoid pharmacology to date. This work traces the history of glucocorticoid biology from the seminal description of glucocorticoid insufficiency by Thomas Addison in the mid-19th century, up to current advances in elucidating the molecular basis of glucocorticoid action. Important discoveries are presented, as well as milestones in drug development, a survey of current clinical practice, and prospects for novel glucocorticoid-based therapeutics. Scientists and clinicians will appreciate the scope of this work, which is of special interest to workers in the fields of endocrinology, inflammation and autoimmune disease.