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Molecular Structure and Biological Activity of Steroids

Molecular Structure and Biological Activity of Steroids

Author: Martin Bohl

Publisher: CRC Press

ISBN: 9781351083256

Category: Science

Page: 483

View: 478

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Molecular Structure and Biological Activity of Steroids focuses on the indentification of steroid structural features that control particular biological effects. Steroid geometry plays a critical role in steroid activity; therefore, the results of X-ray crystallographic, NMR spectroscopic, and theoretical studies on structure-activity relationships form an integral part of the book. Well-established observations and proposed models are presented, summarizing knowledge of molecular features (e.g., steroid backbone structures, side-chain constitutions, substitution sites, configurations, hydrogen-bonding patterns) that can affect steroid action. The book also provides overviews about recent progress in various frontier fields of steroid research, including such areas as sex steroids, glucocorticoids, aromatase inhibitors, vitamin D metabolites, brassinosteroids, neuromuscular blocking agents, and cardiotonic steroids. Molecular Structure and Biological Activity of Steroids is a "must-have" resource for biochemists, pharmacologists, endocrinologists, biophysicists, and others actively involved in steroid research.

Molecular Structure and Biological Activity of Steroids

Molecular Structure and Biological Activity of Steroids

Author: Martin Bohl

Publisher: CRC Press

ISBN: 084936955X

Category: Science

Page: 495

View: 695

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Molecular Structure and Biological Activity of Steroids focuses on the indentification of steroid structural features that control particular biological effects. Steroid geometry plays a critical role in steroid activity; therefore, the results of X-ray crystallographic, NMR spectroscopic, and theoretical studies on structure-activity relationships form an integral part of the book. Well-established observations and proposed models are presented, summarizing knowledge of molecular features (e.g., steroid backbone structures, side-chain constitutions, substitution sites, configurations, hydrogen-bonding patterns) that can affect steroid action. The book also provides overviews about recent progress in various frontier fields of steroid research, including such areas as sex steroids, glucocorticoids, aromatase inhibitors, vitamin D metabolites, brassinosteroids, neuromuscular blocking agents, and cardiotonic steroids. Molecular Structure and Biological Activity of Steroids is a "must-have" resource for biochemists, pharmacologists, endocrinologists, biophysicists, and others actively involved in steroid research.

Spectroscopic Data of Steroid Glycosides

Spectroscopic Data of Steroid Glycosides

Author: Anwer Basha

Publisher: Springer Science & Business Media

ISBN: 9780387395722

Category: Science

Page: 706

View: 157

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Spectroscopic Data of Steroid Glycosides serves as an essential reference guide containing spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids. All compounds are arranged according to the structure of the aglycone, and, in its own class, according to the increasing molecular weight, making Spectroscopic Data of Steroid Glycosides extremely useful for the structure elucidation of new natural products, particularly glycosides. Spectroscopic Data of Steroid Glycosides offers a practical desk reference for all scientists and students interested in steroid glycosides and their biological and medicinal importance. The following data of the steroid glycosides, as available in published literature, are included: - Name of the compound, Chemical name of compound and its structure, - Source, name of the genus, species, authors, family of the biological source from which the glycoside has been isolated, - Melting point, - Specific rotation, - Molecule weight, - Molecular formula, - UV spectral data : maxima, e or log e , solvent, - IR peaks in cm-1 with medium in which the spectrum was taken e.g. KBr, nujol, etc, - Proton magnetic resonance (PMR) chemical shifts, multiplicity of the peaks, coupling constants with assignments, - 13C-NMR (CMR) chemical shifts with assignments, - Mass spectral data with the technique used (e.g. Electron Impact (E.I.), Fast Atom Bombardment (FAB), positive ion or negative ion mode or any other technique, - CD or ORD data, - Biological Activity, - Full reference from which data have been taken.

Chemistry and Biological Activity of Steroids

Chemistry and Biological Activity of Steroids

Author: Jorge António Ribeiro Salvador

Publisher: BoD – Books on Demand

ISBN: 9781789855159

Category: Science

Page: 142

View: 727

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The steroid scaffold continues to be the structural basis of new drugs for a variety of targets and diseases. Indeed, steroids interact with enzymes and receptors in a strikingly specific manner. Chemistry and Biological Activity of Steroids aims to provide an updated overview of recent advances in the medicinal chemistry of steroids. Novel synthetic methods in the steroids field, including steroid biotransformations, new steroids able to tackle steroid receptors, and steroid enzymes with clinical relevance, are critically reviewed in this book. Furthermore, the diverse physiopathological roles of oxysterols and their therapeutic value are also discussed.

Spectroscopic Data of Steroid Glycosides

Spectroscopic Data of Steroid Glycosides

Author: Viqar Uddin Ahmad

Publisher: Springer Science & Business Media

ISBN: 9780387395784

Category: Science

Page: 696

View: 851

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This book is an essential reference guide to spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids. All compounds are arranged according to the structure of the aglycone, and, in its own class, by the increasing molecular weight, making Spectroscopic Data of Steroid Glycosides extremely useful for the structure elucidation of new natural products, particularly glycosides.

Spectroscopic Data of Steroid Glycosides

Spectroscopic Data of Steroid Glycosides

Author: Viqar Uddin Ahmad

Publisher: Springer Science & Business Media

ISBN: 9780387395760

Category: Science

Page: 696

View: 251

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This book is an essential reference guide to spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids. All compounds are arranged according to the structure of the aglycone, and, in its own class, by the increasing molecular weight, making Spectroscopic Data of Steroid Glycosides extremely useful for the structure elucidation of new natural products, particularly glycosides.

Atlas of Steroid Structure

Atlas of Steroid Structure

Author: William L. Duax

Publisher: Springer

ISBN: MINN:319510000020475

Category: Science

Page: 586

View: 926

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The crystal structure determinations of over 235 natural and synthetic steroid molecules reported from 1945 to 1974 constitute the most detailed block of structural data on any class of biologically active molecules in existence and provide a wealth of raw material concerning molecular con formation and intermolecular interactions ideally suited to the analysis of structure-function correlations. Volumes of physiological data gener ated in studies ranging from simple dose-response characterizations to elegant examination of receptor binding sites make up the functional counterpart to this structural data reservoir. The utilization of these data for purposes of exploring biochemical reactions at the molecular level has been inhibited by lack of communication among structural chemists, bio chemists, and clinicians. The typical non-crystallographer in the fields of biochemistry and endocrinology finds it difficult to interpret structure reports. The molecular features of key importance from his point of view are often omitted, and, although atomic coordinates are usually tabulated, he may be unable to calculate the details which he needs. Structure reports on steroids have often been published in obscure journals and in some cases the paper has been extremely brief and no mention of the biological importance of the material has been made. Lack of uniformity in presen tation of data has also been an impediment to utilization of these data by non-crystallographers. Similarly, the average crystallographer has difficulty assessing data concerning biological activity.

Spectroscopic Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides

Spectroscopic Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides

Author: Viqar Uddin Ahmad

Publisher: Springer Science & Business Media

ISBN: 9780387395746

Category: Science

Page: 686

View: 878

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This book is an essential reference guide to spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids. All compounds are arranged according to the structure of the aglycone, and, in its own class, by the increasing molecular weight, making Spectroscopic Data of Steroid Glycosides extremely useful for the structure elucidation of new natural products, particularly glycosides.

Spectroscopic Data of Steroid Glycosides

Spectroscopic Data of Steroid Glycosides

Author: Anwer Basha

Publisher: Springer Science & Business Media

ISBN: 9780387395715

Category: Science

Page: 696

View: 511

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This book is an essential reference guide to spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids. All compounds are arranged according to the structure of the aglycone, and, in its own class, by the increasing molecular weight, making Spectroscopic Data of Steroid Glycosides extremely useful for the structure elucidation of new natural products, particularly glycosides.

Steroid Chemistry at a Glance

Steroid Chemistry at a Glance

Author: Daniel Lednicer

Publisher: John Wiley & Sons

ISBN: 9781119957294

Category: Science

Page: 152

View: 428

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The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted as "Steroid Chemistry". Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Topics covered include: history, isolation and structure determination of steroids steroid nomenclature and stereochemistry natural sources of steroids synthesis and reactions of aromatic a-ring steroids, androstanes, and pregnanes steroids with a spirolactone at position 17 steroids with hetrocyclic ring A compounds derived from cholesterol Based on the highly successful and student friendly "at a glance" approach, the information is presented in integrated, self contained double page spreads of text and illustrative material. Students of chemistry and pharmacy using Steroid Chemistry at a Glance will find they have a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural products. It will also serve as a handy bench reference for postgraduates and professional chemists.

Spectroscopic Data of Steroid Glycosides

Spectroscopic Data of Steroid Glycosides

Author: Viqar Uddin Ahmad

Publisher: Springer

ISBN: 0387563350

Category: Science

Page: 696

View: 846

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This book is an essential reference guide to spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids. All compounds are arranged according to the structure of the aglycone, and, in its own class, by the increasing molecular weight, making Spectroscopic Data of Steroid Glycosides extremely useful for the structure elucidation of new natural products, particularly glycosides.